• In the 19th century, there were several sideshow performers billed variously as The Elastic Skin Man, The India Rubber Man and Frog Boy. They included such well known individuals (in their time) as Felix Wehrle, James Morris and Avery Childs.

• Several current celebrities have EDS:

  • Actress Cherylee Houston has type 3 EDS and uses a wheelchair; she made history by becoming Coronation Street '​s first full-time disabled actress.

  • The condition may have contributed to the virtuoso violinist Niccolò Paganini's skill as he was able to play wider fingerings than the normal violinist.  

  • Eric Shaun Lynch aka Eric the Midget and later Eric the Actor, a member of Howard Stern's Wack Pack had Ehlers–Danlos Syndrome Type VII.

  • Adult film star Mandy Morbid has discussed the impact EDS has on her mobility and her life. 

  • Rei Haycraft, lead singer for the hard rock band, Raimee, artist, and illustrator. Haycraft has created songs and a documentary about living with Ehlers-Danlos, as well as written songs about its impact on her life. 

• The condition is mentioned in the song "Dorsal Horn Concerto" by the British comedy band the Amateur Transplants. 

• The condition has been mentioned in many television shows, including:

  • CSI New York in the Season 1 episode, "Blood, Sweat and Tears."

  • FOX series Bones in the Season 4 episode "The Perfect Pieces in the Purple Pond."

  • House in the episodes "House's Head" (Season 4, Episode 15) and "The Dig (House)" (Season 7, Episode 18).

  • The Law & Order episode "Dignity" (Season 20, Episode 5). In the episode, a third-trimester fetus is diagnosed with the condition and is slated for abortion; shortly later, the doctor who is due to perform the abortion is murdered in church.

  • USA Network series Royal Pains episode "After the Fireworks" (Season 4, Episode 1).

  • The subject of the Season 7 premiere of the A&E series Intervention, Linda, claims to have EDS. 

  • "The Doctors" Cirque Du Soleil's "O" episode. In this episode, the doctors discuss flexibility and EDS

 

 

In other animals Ehlers–Danlos-like syndromes have been shown to be hereditary in Himalayan cats, some domestic short hair cats, and in certain breeds of cattle. It is seen as a sporadic condition in domestic dogs. Degenerative suspensory ligament desmitis (DSLD) is a similar condition seen in many breeds of horses. Though it was originally notated in the Peruvian Paso and thought to be a condition of overwork and older age, the disease is being recognized in all age groups and all activity levels. It has even been noted in newborn foals. The latest research has led to the renaming of the disease as Equine Systemic Proteoglycan Accumulation, after the possible systemic and hereditary components now being delineated by the University of Georgia.